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This essay looks at the historical significance of two APS classic papers that are freely available online: Pitts RF and Alexander RS. The nature of the renal tubular mechanism for acidifying the urine. Am J Physiol 144: 239 -254, 1945 (http://ajplegacy.physiology. org/cgi/reprint/144/2/239). Pitts RF and Lotspeich WD. Bicarbonate and the renal regulation of acid base balance.doi:10.1152/classicessays.00005.2004 pmid:15475538 fatcat:iypl3b5k2neurmp6jlehuolzeq