Haplotype Analysis in Icelandic Families Defines a Minimal Interval for the Macular Corneal Dystrophy Type I Gene

Ning-Pu Liu, Jennifer Baldwin, Fridbert Jonasson, Susan Dew-Knight, Jeffrey M. Stajich, Felicia Lennon, Margaret A. Pericak-Vance, Gordon K. Klintworth, Jeffery M. Vance
1998 American Journal of Human Genetics  
Letters to the Editor human, tissue-specific differences in the function of MYO7A might result in specific mutations having different effects in the eye but similar effects in the inner ear. It seems likely, however, given (a) the wide range of MYO7A mutations identified for both nonsyndromic deafness and USH and (b) the results reported in the present study, that genetic background effects have some role to play in determining the development and severity of nonsyndromic and syndromic hearing loss.
doi:10.1086/302001 pmid:9718332 pmcid:PMC1377390 fatcat:cs4twnlyuzenljhtxigu643hp4