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Atypical kinetics has been observed in vitro for both cytochrome P450 and UDP-glucuronosyltransferase catalyzed enzymatic reactions. The in vitro and in vivo kinetics of valproic acid-glucuronide (VPA-glucuronide) formation was investigated in humans. VPA-glucuronide formation kinetics was investigated in vitro using human cryoperserved hepatocytes (pool of 10). Estimates of V max app (39.5 ± 3.3 pmol/min/10 6 cells), S 50 app (224 ± 34 µM) and n (2.34 ± 0.28) was obtained by fittingdoi:10.4172/2153-2435.s11-006 fatcat:4lchymj6nrfo5ct7q5owcyn3le