Association between vitamin D deficiency and anemia among Korean adolescent girls and young women

Haeun Jang, Seonghee Park, Kyong Park
2019 Journal of Nutrition and Health  
Purpose: Although vitamin D deficiency is common among Korean adolescent girls and young women, few studies have explored the potential health effects of vitamin D deficiency in this vulnerable population. This study examined the association between vitamin D deficiency and anemia in Korean adolescent girls and young women. Methods: The data from the Korea National Health and Nutrition Examination Survey 2008~2014 were used. A total of 3,643 girls and adult women aged 12 to 29 who provided all
more » ... he information (including serum 25-hydroxy vitamin D, hemoglobin, and/or serum ferritin) needed for the analysis were included in the analysis. Demographic, lifestyle, and health data were obtained through survey questionnaires. Anemia and iron deficiency anemia were defined according to the World Health Organization cut-offs. Multivariable logistic regression, and restricted cubic spline regression were used in the analysis. Results: In fully adjusted logistic regression models, the vitamin D deficiency was significantly associated with higher prevalences of anemia (odds ratio (OR): 1.61, 95% confidence interval (CI): 1.04~2.49) and iron deficiency anemia (OR: 1.43, 95% CI: 1.01~2.03). In a cubic spline regression model, we observed a dose-response relationship between serum 25(OH)D concentration and anemia, and this linear relationship was also clearly observed between serum 25(OH)D concentration and iron deficiency anemia. Conclusion: Vitamin D deficiency may be associated with a higher prevalence of iron deficiency anemia and anemia in adolescent girls and young women. Alternatively, vitamin D deficiency may be a concurrent event for patients with anemia, which we cannot distinguish in this cross-sectional study. Further studies are needed to verify the causality in this population of low vitamin D levels. (http://creativecommons. org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 서 론 우리나라는 최근 비타민 D 결핍으로 인한 환자수와 진 료비가 꾸준히 증가하는 추세를 보이고 있으며 [1], 그 중 10~20대 여성의 비타민 D 결핍률이 다른 연령대에 비해 현저하게 높은 것으로 보고되었다 [2]. 비타민 D 결핍은 근골격 건강 및 심혈관 질환을 포함한 수많은 만성질환 위 험을 높이며, 특히 젊은 여성들의 비타민 D 결핍은 노년기 의 골 관련 질환 발생 위험을 증가시키는 등 심각한 결과 로 이어질 수 있다 [3,4]. 최근 비타민 D 결핍은 빈혈을 유발시킬 수 있다는 선행 연구가 보고되고 있다. 체내 비타민 D는 철 조절호르몬인 헵시딘 (hepcidin)에 영향을 주고, 이러한 작용으로 혈청 철분 농도가 감소하여 빈혈을 유발할 수 있다는 메커니즘 이 제시되었다 [5]. 특히, 아동 및 청소년기는 성장으로 인 해 철 요구량이 증가되어 상대적인 철 부족 상태가 나타날
doi:10.4163/jnh.2019.52.6.552 fatcat:rfbzrxvu4vdipdvqkpet67wlza