Evaluation of the ADVIA® Centaur™ TSH-3 Assay

Michael Vogeser, Michael Weigand, Peter Fraunberger, Heike Fischer, Peter Cremer
2000 Clinical Chemistry and Laboratory Medicine  
An analytical evaluation of the thyroid stimulating hormone (TSH-3) assay on the Bayer ADVIA ® Centaur™ immunoassay system was performed. General analytical requirements (linearity, resistance to typical interferences, absence of a carry-over effect) were fulfilled and reproducibility was satisfactory. Inter-assay coefficient of variation (CV) of a human serum pool with a concentration of 0.014 mU/l was 22.3%; at concentrations between 0.26 and 83 mU/l CV was below 6%. Method comparison study
more » ... comparison study demonstrated close agreement of TSH results compared to those obtained with the Roche Elecsys ® 2010 TSH assay (ADVIA Centaur = 1.08 x Elecsys -0.18 mU/l; r=0.987; n=324). Handling and practicability of the ADVIA Centaur system proved to be convenient with a very high sample throughput. We conclude that the ADVIA Centaur TSH-3 assay meets requirements for clinical use.
doi:10.1515/cclm.2000.048 pmid:10928654 fatcat:mfu6lgopwfartmd5l4azylqhpe