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Cardiovascular disorders include various conditions characterized by morphological and functional defects of the heart and vascular system. Molecular biology techniques (in particular DNA sequencing) have recently offered new insights into the etiology of cardiovascular defects, revealing their association with germline as well as somatic mutations. Genetic tests are evaluated on the basis of their analytical and clinical validity, clinical utility, and ethical, legal and social implications.doi:10.2478/ebtj-2018-0023 fatcat:6ascq2tlyjaglju73ymhw7vkby