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H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias
2008
Cancer Cell
We created a mouse model wherein conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Gene expression profile analysis of the ALL cells demonstrated significant overlap with human MLL-rearranged ALL. ChIP-chip analysis demonstrated histone H3 lysine 79 (H3K79) methylation profiles that correlated with Mll-AF4-associated gene expression profiles in murine ALLs and in human MLL-rearranged leukemias. Human
doi:10.1016/j.ccr.2008.10.001
pmid:18977325
pmcid:PMC2591932
fatcat:x3ltqr6l4fad7owrzihm3vf22m