Purpose: The role of vitamin D in traditional atopic disorders (i.e., asthma, allergic rhinitis, and atopic dermatitis) is still uncertain. We have analyzed the association between serum 25-hydroxyvitamin D3 (25(OH)-D3) levels and asthma in children. Methods: A total of 133 children were enrolled between April 2008 and December of 2008. Children were divided into 3 groups: the asthma group (n = 80), bronchiolitis group (n = 50), and normal group (n = 35). Serum samples were collected and

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... for 25(OH)-D3 levels. From the blood samples, we measured eosinophil counts, total IgE, specific IgE (Dermatophagoides pteronyssinus, Dermatophagoides farinae, milk, egg, cat, dog, cockroach) (Uni-CAP FEIA system). Results: The mean age of the patients was 4.6 years. The mean 25(OH)-D3 levels of the asthma, bronchiolitis, and normal groups were 17.2± 8.9, 22.5± 9.3, and 27.8± 10.2 ng/mL, respectively (P< 0.01). There was no association between allergens and vitamin D levels. Mean 25(OH)-D3 levels were lower at acute state of asthma than at stable state. Conclusion: The mean level of 25(OH)-D3 was associated with asthma and acute state of asthma. Further experimental and clinical studies are needed to establish a definite link between vitamin D levels and asthma. (Allergy Asthma Respir Dis 2016;4:44-48)