Machine learning-enabled multiplexed microfluidic sensors

Sajjad Rahmani Dabbagh, Fazle Rabbi, Zafer Doğan, Ali Kemal Yetisen, Savas Tasoglu
2020 Biomicrofluidics  
High-throughput, cost-effective, and portable devices can enhance the performance of point-of-care tests. Such devices are able to acquire images from samples at a high rate in combination with microfluidic chips in point-of-care applications. However, interpreting and analyzing the large amount of acquired data is not only a labor-intensive and time-consuming process, but also prone to the bias of the user and low accuracy. Integrating machine learning (ML) with the image acquisition
more » ... of smartphones as well as increasing computing power could address the need for high-throughput, accurate, and automatized detection, data processing, and quantification of results. Here, ML-supported diagnostic technologies are presented. These technologies include quantification of colorimetric tests, classification of biological samples (cells and sperms), soft sensors, assay type detection, and recognition of the fluid properties. Challenges regarding the implementation of ML methods, including the required number of data points, image acquisition prerequisites, and execution of data-limited experiments are also discussed.
doi:10.1063/5.0025462 pmid:33343782 pmcid:PMC7733540 fatcat:i6b7zqfyobbyxgctxb6tlr5k54