This paper presents a SoC (System-on-a-Chip) dedicated for a single-chip smart capsule which can be used to continuously monitor human alimentary canal pH and temperature values. The SoC is composed of the pH and temperature sensor interface circuit, a wireless transceiver, the power management circuit and the flow control logic. Fabricated in 0.18 μm standard CMOS technology, the SoC occupies a die area of ~9 mm 2 . The SoC consumes 6.15 mW from a 3 V power supply, guaranteeing the smart

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... e battery life is no less than 24 hours when using 50 mAh coin batteries. The experimental results show that measurement accuracy of the smart capsule is ±0.1 pH and ±0.2°C for pH and temperature sensing, respectively, which meets the requirement of in-body pH and temperature monitoring in clinical practice. Index Terms-System-on-a-Chip (SoC), pH sensor, temperature sensor, transceiver, smart capsule