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Human natural killer (NK) cells are defined as CD56 + CD3 À . Despite its ubiquitous expression on human NK cells the role of CD56 (NCAM) in human NK cell cytotoxic function has not been defined. In non-immune cells, NCAM can induce signaling, mediate adhesion, and promote exocytosis through interactions with focal adhesion kinase (FAK). Here we demonstrate that deletion of CD56 on the NK92 cell line leads to impaired cytotoxic function. CD56-knockout (KO) cells fail to polarize duringdoi:10.7554/elife.57346.sa2 fatcat:7hoft6z4fvgfvl43ro24qsvqq4