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Monocyte NADPH Oxidase Subunit p22phoxand Inducible Hemeoxygenase-1 Gene Expressions Are Increased in Type II Diabetic Patients: Relationship with Oxidative Stress
2003
Journal of Clinical Endocrinology and Metabolism
Oxidative stress is associated with diabetes mellitus: a role of vascular NADPH oxidase as a source of superoxide has been demonstrated. We determined whether in type 2 diabetes mononuclear cells, NADPH oxidase and the inducible hemeoxygenase (HO-1) gene expressions are activated. In monocytes from 25 outpatients with type 2 diabetes, p22 phox gene expression was higher (0.71 ؎ 0.09 p22 phox /-actin gene expression ratio) than that observed in 19 controls (0.56 ؎ 0.09, P < 0.001). Similarly,
doi:10.1210/jc.2002-021025
pmid:12679469
fatcat:xgmom3k2zfevhjc4lkzljoxiii