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Microglia-Specific Promoter Activities of HEXB Gene
2022
Frontiers in Cellular Neuroscience
Adeno-associated virus (AAV)-mediated genetic targeting of microglia remains a challenge. Overcoming this hurdle is essential for gene editing in the central nervous system (CNS). Here, we characterized the minimal/native promoter of the HEXB gene, which is known to be specifically and stably expressed in the microglia during homeostatic and pathological conditions. Dual reporter and serial deletion assays identified the critical role of the natural 5' untranslated region (−97 bp related to the
doi:10.3389/fncel.2022.808598
pmid:35360489
pmcid:PMC8960132
fatcat:d2oz5y6bojfdvmdaon7fghe454