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Suppression of Hydrogen Peroxide-Induced Cytotoxicity toward Chinese Hamster Lung Fibroblasts by Chemically Modified Curcumin
1997
Food Science and Technology International Tokyo
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We assessed the inhibitory effects of curcumin and its chemically modified homologues against H202-induced cytotoxicity toward Chinese hamster lung fibroblasts V79 cells with a colony formation assay. Among 4 curcuminoids, dihydroxycurcumin and dihydroxytetrahydrocurcumin suppressed H202-induced cytotoxicity. On the contrary, neither curcumin nor tetrahydrocurcumin showed any suppressive effects. These results support our empirical rule that the o-dihydroxy (catechol) moiety is essential for the inhibitory effects.
doi:10.3136/fsti9596t9798.3.74
fatcat:clsqf6tsxrgyvaj2gxalt62wfm