PARAMETER IDENTIFICATION VIA THE ADJOINT METHOD: APPLICATION TO PROTEIN REGULATORY NETWORKS

Robin L. Raffard, Keith Amonlirdviman, Jeffrey D. Axelrod, Claire J. Tomlin
2006 IFAC Proceedings Volumes  
An adjoint-based algorithm for performing automatic parameter identification on differential equation based models of biological systems is presented. The algorithm solves an optimization problem, in which the cost reflects the deviation between the observed data and the output of the parameterized mathematical model, and the constraints reflect the governing parameterized equations themselves. Preliminary results of the application of this algorithm to a previously presented mathematical model
more » ... of planar cell polarity signaling in the wings of Drosophila melanogaster are presented.
doi:10.3182/20060402-4-br-2902.00475 fatcat:3cjx5sksczchfnvslf6q53zbii