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PARAMETER IDENTIFICATION VIA THE ADJOINT METHOD: APPLICATION TO PROTEIN REGULATORY NETWORKS
2006
IFAC Proceedings Volumes
An adjoint-based algorithm for performing automatic parameter identification on differential equation based models of biological systems is presented. The algorithm solves an optimization problem, in which the cost reflects the deviation between the observed data and the output of the parameterized mathematical model, and the constraints reflect the governing parameterized equations themselves. Preliminary results of the application of this algorithm to a previously presented mathematical model
doi:10.3182/20060402-4-br-2902.00475
fatcat:3cjx5sksczchfnvslf6q53zbii