Solvent-free synthesis of polyhydroquinoline and 1,8-dioxodecahydroacridine derivatives through the Hantzsch reaction catalyzed by a natural organic acid: A green method

Imène Sehout, Raouf Boulcina, Boudjemaa Boumoud, Taous Boumoud, Abdelmadjid Debache
2017 Figshare  
Solvent-free and high yielding one-pot synthesis of 1,8-dioxodecahydroacridine and polyhydroquinoline derivatives have been described through Hantzsch condensation of various aldehydes, ammonium acetate with cyclic 1,3-dicarbonyl compounds and ethyl acetoacetate in a very simple, efficient, and environmentally benign method using ascorbic acid as a nontoxic organocatalyst.
doi:10.6084/m9.figshare.4868723 fatcat:begr5pie3rdzbge64cwdqpib5q