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Novel endonuclease in Archaea cleaving DNA with various branched structure
2002
Genes & Genetic Systems
We identified a novel structure-specific endonuclease in Pyrococcus furiosus. This nuclease contains two distinct domains, which are similar to the DEAH helicase family at the N-terminal two-third and the XPF endonuclease superfamily at the C-terminal one-third of the protein, respectively. The C-terminal domain has an endonuclease activity cleaving the DNA strand at the 5'-side of nicked or flapped positions in the duplex DNA. The nuclease also incises in the proximity of the 5'-side of a
doi:10.1266/ggs.77.227
pmid:12419895
fatcat:pwl52fwlnngztmnmtxwkdndpjy