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Development of a physiological insulin resistance model in human stem cell-derived adipocytes
[article]
2022
bioRxiv
pre-print
AbstractAdipocytes are key regulatory cells of human metabolism, and their dysfunction in insulin signaling is central to metabolic diseases such as type II diabetes mellitus (T2D). However, the progression of insulin resistance that leads to T2D is still poorly understood. This limited understanding is due, in part, to the dearth of suitable models of insulin signaling in human adipocytes. Traditionally, in vitro adipocyte models fail to recapitulate in vivo insulin signaling, possibly due to
doi:10.1101/2022.02.22.481495
fatcat:w2tyw6cpujhz3f6icz2yarc6am