Long-term effects of balloon angioplasty on systemic hypertension in adolescent and adult patients with coarctation of the aorta

M Fawzy
1999 European Heart Journal  
Aims To define the long-term effect of balloon angioplasty of aortic coarctation on hypertension, in adolescent and adult patients. Methods Balloon angioplasty of discrete, native aortic coarctation was performed on 50 patients (34 male) aged 23 8 (mean standard deviation) years. In 42 of these patients cardiac catheterization and angiography were repeated 1 year later, and on the basis of sphygmomanometric blood pressure determination at that time, they were divided into 31 patients (group A)
more » ... ith normalized blood pressure and 11 patients (group B) who still needed antihypertensive medication. Both groups were followed annually thereafter for 12-123 (66 37) months. Results Coarctation gradient values before, immediately after and 1 year after angioplasty were 69 24 mmHg, 12 8 mmHg (P<0·001) and 7 6 mmHg. The corresponding systolic blood pressure values were 165 17 mmHg, 128 12 mmHg (P<0·001) and 115 10 mmHg (P<0·001) in group A; 182 21 mmHg, 141 24 mmHg (P<0·001) and 134 18 mmHg (P<0·001) in group B. Echocardiographic left ventricular mass index before angioplasty and at follow-up was 130 31 g . m 2 and 105 23 g . m 2 in group A; 157 38 g . m 2 and 132 35 g . m 2 in group B (P<0·001 for both comparisons). Conclusion Normalization of blood pressure without medication occurred in 74% of patients after angioplasty for aortic coarctation, with subsequent long-term regression of left ventricular hypertrophy. In comparison to reported surgical results, balloon angioplasty should be considered as first line treatment for native, discrete aortic coarctation in adolescent and adult patients. (Eur Heart J 1999; 20: 827-832)
doi:10.1053/euhj.1998.1448 pmid:10329081 fatcat:5y4dgc3xerbitdcz5ecq2lh6am