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NFKB1 polymorphism is associated with age-related gene methylation in Helicobacter pylori-infected subjects
2012
International Journal of Molecular Medicine
CpG island aberrant methylation is shown to be an important mechanism in gene silencing. The important role of NF-κB in the inflammatory response to H. pylori colonization has been indicated. We investigated the influence of NFKB1 polymorphisms, -94 ins/del (rs28362491) and -449 C>G (rs72696119), on the aberrant gene methylation under H. pylori infection. Gastric mucosal samples were obtained from subsubjects without malignancies. Methylation status of genes (p14 ARF , p16 INK4a , DAPK and
doi:10.3892/ijmm.2012.1004
pmid:22614238
fatcat:cy5vemiblvbolpc7olu2tlkkay