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The role of vascular smooth muscle inward rectifier K ϩ (K IR ) channels in the mechanisms underlying vasodilation is still unclear. The hypothesis that K IR channels are involved in sodium nitroprusside (SNP)-induced dilation of rat-tail small arteries was tested. SNP relaxed tail small arteries with an EC 50 of 2.6ϫ10 Ϫ8 mol/L. Endothelium removal did not attenuate this effect. Vessel pretreatment with hydroxocobalamin, a nitric oxide (NO) scavenger, but not with rhodanese and sodiumdoi:10.1161/01.hyp.0000121882.42731.6b pmid:14993195 fatcat:wccjbhsotbejbcxv7zqcbmykzm