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This study aims to enhance students' creative thinking skills through the biotechnology module based on socio-scientific issues. This is pre-experimental research with a one-group pretest-posttest design. The learning is carried out online using the Zoom meeting application, which is familiar to the students. The instrument for collecting data is a valid creative thinking skill test sheet. The students' responses were analyzed using a questionnaire. The data analysis was done by descriptivedoi:10.29303/jppipa.v8i2.1438 fatcat:lrfbwou2bze27ifw55zbbby3gq