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Original Article Unfolded protein response mediated JNK/AP-1 signal transduction, a target for ovarian cancer treatment
Int J Clin Exp Pathol
Researches have revealed several stressors, which could activate unfolded protein response (UPR) in cells. However, the survival or death pathway was determined by the duration of UPR exposure. Based on the UPR mediated death pathway, our study was aimed to investigate role of UPR on c-Jun N-terminal kinase (JNK)/activator protein-1 (Ap-1) signal transduction in diindolylmethane (DIM) treated ovarian cancer cell lines. Activation of UPR proteins, UPR mediated apoptotic signaling proteins andfatcat:42syd352xffivofs7yfcooex6e