Clinical Significance of C-reactive protein in Pregnancy Induced Hypertension

2019 ARC Journal of Gynecology and Obstetrics  
Hypertensive disorders of pregnancy contributes significantly to morbidity and mortality in the fetus and mother both in the developed and developing countries with PIH listed as one of the top three causes of maternal mortality. [2] Abstract C -reactive protein (CRP), a marker of inflammation from widespread endothelia injury in PIH may correlate with clinical measures. This study evaluated the association of maternal serum C-reactive concentration with clinical correlates in patients with
more » ... nancy induced hypertension. This was a prospective study in which 44 patients with PIH and 88 controls that satisfied the inclusion criteria were recruited. A p-value<0.05 was considered significant. The mean serum level of CRP was 29.7±17.1µg/ml in women with PIH and 23.5±16.3µg/ml in the normotensive group ((p=0.045); ). Mean serum levels of CRP in women with severe PIH (32.2±16.4µg/ml) was significantly higher (p=0.009) than in women with mild PIH (22.2 ±17.7µg/ml). Babies born to mothers with PIH whose serum CRP levels were above the mean serum CRP had their mean 5 th minute Apgar score (8.1±1.8) significantly lower than the mean 5 th minute Apgar score (8.7±0.7) of babies born to mothers with PIH whose serum CRP levels were below the mean. Serum CRP levels were elevated in women with pregnancy induced hypertension than in normotensive women and more elevated in severe PIH than in mild PIH. It showed reasonable positive correlation with disease severity and adverse fetal outcome that warrants further investigation.
doi:10.20431/2456-0561.0402002 fatcat:i6pyo4dqhbgf5hw3tioukzshxi