With the continuous development of living standards and medical standards, the national life expectancy is prolonged, and the mortality rate of chronic diseases is reduced, this trend has increased the number of elderly people who use daily painkillers to fight chronic pain, while expanding the proportion of elderly surgical population  . It is well known that the elderly have a more special pathophysiological state than the young and middle-aged, which also leads to the clinical use of the
... linical use of the elderly with extreme caution, so it is very important to study the pharmacokinetics (PK) of the elderly. As a common painkiller, opioids are also an essential part of general anesthesia surgery. For decades, domestic and foreign clinical workers have conducted a detailed study on the pharmacokinetics of opioids in order to achieve drug safety and dose precision in elderly patients. Aging affects the pharmacokinetics of opioids by changing body composition and organ function  , and there are many conclusions about the changes in pharmacokinetics caused by various factors, but they are not the same. This article aims to summarize and discuss the research on the pharmacokinetics of opioids in the elderly in recent years, with a view to pointing out the direction for subsequent research.