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New sources and detectors are allowing scientists to look at matter with finer spatial and temporal resolutions. These experiments can produce data that are a series of severely Poisson limited snap-shots of randomly oriented samples. An extreme case of this is destructive imaging of single particles with an x-ray free-electron laser -many frames are needed for a reconstruction, but there is no a priori information associated with the frames about particle orientation. We use Cornell's Pixeldoi:10.1088/1742-6596/425/19/192016 fatcat:de77vgv6ozhynd677v4agzhfaa