The present study was aimed to evaluate the fractions of Antigonon leptopus Hook & Arn leaf for their antidiabetic potential on streptozotocin-induced diabetes in neonatal rats. The methanolic extract of the leaves of A.leptopus (MAL) had showed significant oral glucose tolerance at 200 mg/kg body weight, which was conducted in our labs. Oral administration of toluene, ethyl acetate, and butanone fractions of A.leptopus leaf (TMAL, EAMAL, BNMAL) at 50 and 100 mg/kg b.w significantly reduced the

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... fasting blood glucose level in diabetic rats. Among these fractions, EAMAL was found to be more effective. Further, the effects of EAMAL on fasting blood sugar level and serum biochemical analysis in Streptozotocin-induced diabetic rats were investigated. The results revealed that EAMAL exhibited significant antidiabetic activity and substantiating the traditional medicinal claim of the leaves of A.leptopus in the treatment of diabetes.