The metabolic syndrome: similar deleterious impact on all-cause mortality in hypertensive and normotensive subjects

Bruno Pannier, Frédérique Thomas, Kathy Bean, Bertrand Jégo, Athanase Benetos, Louis Guize
2008 Journal of Hypertension  
Objectives Few data are available on the impact of the metabolic syndrome on all-cause mortality risk according to the presence of hypertension. Our aim was to evaluate the 5-year impact of the metabolic syndrome, according to blood pressure status, on all-cause mortality risk in a large French population. Methods The study population included 39 998 men and 20 756 women with no personal history of cardiovascular disease, who had a health check-up at the IPC Center (Paris, France) between 1999
more » ... nd 2002, and who were followed up for 4.7 W 1.2 years. The metabolic syndrome was defined according to the National Cholesterol Educational Program classification (2001). Cox regression models were used to evaluate risk of all-cause mortality after adjustment for age, sex, classical risk factors and socioeconomic categories. Subjects were classified according to blood pressure status: hypertensive subject (systolic blood pressure > -140 mmHg and/or diastolic blood pressure > -90 mmHg or treatment) and normotensive subject. Results The risk of all-cause mortality associated with the metabolic syndrome was 1.50 (1.24-1.82) [hazard ratio (HR) (95% confidence interval)]. The risk of all-cause mortality associated with the presence of hypertension was 1.60 (1.38-1.85). During the 4.7 years of follow-up, the impact of the metabolic syndrome was similar among normotensive and hypertensive subjects [HR: 1.09 (0.68-1.75) and 1.40 (1.13-1.74), respectively, P for interaction U 0.35]. Conclusion The findings from this study show that, in a large middle-aged French population, the metabolic syndrome has the same deleterious impact on all-cause mortality in hypertensive subjects and normotensive subjects.
doi:10.1097/hjh.0b013e3282fd9936 pmid:18475161 fatcat:r2xsmfgso5e3lix7owk33zsjcm