SCREENING IgM AND IgG ANTIBODIES TO CHLAMYDOPHILA PNEUMONIAE BY ENZYME IMMUNOASSAY (EIA) IN PAEDIATRIC LRTIs IN A TERTIARY HOSPITAL EXPERIENCE IN KOSHI AREA (NORTHERN BIHAR), INDIA
English

Rajiv Kumar, Syed Khursheed Ejaz, Chandan Kumar Poddar, Ram Nagina Sinha, Randhir Kumar, Pappu R K, Bibha Kumari, Santosh Kumar
2016 Journal of Evolution of Medical and Dental Sciences  
BACKGROUND Paediatric Lower Respiratory Tract Infections (LRTIs) are a leading cause of mortality and morbidity in children. Chlamydophila pneumoniae (C. pneumoniae) is one of the new emerging infectious agents with a spectrum of clinical manifestations including lower and upper respiratory tract infections. MATERIALS AND METHODS We investigated 100 children of age 5 months to 12 years hospitalised for community-acquired LRTIs with use of serological tests that included solid phase
more » ... assays (EIA) for detecting anti-C. pneumoniae immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies. RESULTS Serological evidence of C. pneumoniae infection was observed in 6 (6%) patients. Specific IgM antibodies were detected in 5 (83.33%) of these 6 patients, specific IgM and IgG antibodies were detected in none of the patients, specific IgG antibodies in 1 (16.66%) patients and a 4-fold rise in C. pneumoniae antibody IgG titre alone in none of the patients. CONCLUSION This study confirms that C. pneumoniae plays a role in lower respiratory tract infections in Indian children. EIA is feasible and less time consuming method and can be employed for effective treatment and management.
doi:10.14260/jemds/2016/1437 fatcat:g7dlqhq75fahjazrrp4qxavmjq