COLD, FIZZY AND PERFORATING A PAIN IN THE BRAIN?

H Loh, Dap Cooke
2005 CME February   unpublished
C A S E R E P O R T As we head through summer-and it feels as though it has been a long hot one-this interesting case report from Australia may seem pertinent. Hui Loh and David Cooke report a rare case of spontaneous intramural oesophageal perforation after rapid swallowing of a cold carbonated drink. A 57-year-old woman presented to her local emergency department with sudden retrosternal chest pain immediately after she had swallowed a large mouthful of a cold carbonat-ed drink directly from
more » ... he bottle. The first experience of this severe pain led to a brief loss of consciousness. She described the pain as continuous, made worse by swallowing and accompanied by mild nausea but no vomiting. Previously well, she had a mild fever and appeared distressed by the pain. Examination showed only epigastric tenderness with retroster-nal radiation. She had a mildly elevated white cell count and normal chest X-ray and ECG. A CT scan of the thorax showed a tiny bubble of gas, either within the wall of the oesophagus or just adjacent to it in the middle mediastinum. The authors note that this did not rule out a full perforation of the oesophagus. The woman was admitted and managed nil by mouth, with intravenous fluids and triple antibiotic therapy, which included ampicillin, gentamicin and metronidazole. She was given intravenous omeprazole three times daily and observed closely. Her fever resolved within 24 hours, but her C-reactive protein rose over the same period. A second CT scan with water-soluble contrast showed intramural contrast with no extravasa-tion, consistent with a partial perforation of the oesophagus. Gastroscopy showed a 10 cm longitudinal mucosal/submu-cosal tear in the left posterolateral wall of the oesophagus, 3 cm above the gastro-oesophageal junction. Conservative treatment was continued and the patient's symptoms improved. She started on clear fluids on day 4, progressed to a soft diet and was discharged on day 7. She continued oral omeprazole 40 mg daily. Four weeks later she still had mild dysphagia and a repeat gastroscopy showed healing scar tissue with no sign of a stricture. Boerhaave's syndrome or spontaneous perforation of the oesophagus classically follows forceful vomiting. The syndrome is a form of barogenic rupture caused by a rapid rise in intraluminal pressure when there is sudden distension of the oesophagus. The authors suggest that in this case the rapid swallowing of the cold drink led to spasm of the distal oesoph-agus followed by effervescent expansion, resulting in a rapid build-up of intra-oesophageal pressure. It is a serious condition. Among those who experience complete perforation, mortality is 13-25% if treated within 24 hours of symptoms starting , 33-65% if treated 24-48 hours after the onset of symptoms , and 89% if treated after more than 48 hours. Weakening of the oesophageal wall, for example through reflux oesophagitis, infectious oesophagitis, Barrett's ulceration or oesophageal cancer, predisposes to the syndrome.
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