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Chemical Lesion of the Bed Nucleus of the Stria Terminalis Blocks the Behavioral Consequences of Uncontrollable Stress

Sayamwong E. Hammack, Kristen J. Richey, Linda R. Watkins, Steven F. Maier
2004 Behavioral Neuroscience  

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Uncontrollable or inescapable shock (IS) produces behavioral changes that are characterized by a sensitized fear system and a deficit in fight-flight responding. These behavioral changes have been argued to represent an anxiety-like state produced by the uncontrollability of the stressor. The bed nucleus of the stria terminalis (BNST) has been implicated in the mediation of long-duration responses to unpredictable stressors, which have also been argued to represent anxiety. In the present
more » ... the effects of BNST chemical lesion on the IS-induced sensitization of freezing to an environment previously paired with shock and the IS-induced impairment of escape responding were investigated. BNST chemical lesion blocked the potentiation of freezing and the increases in escape latency that normally follow IS. Method Subjects Male Sprague-Dawley rats (Harlan Labs, Madison, WI) weighing 275-325 g were used in all experiments. Rats were single-housed and main-
doi:10.1037/0735-7044.118.2.443 pmid:15113272 fatcat:3lzxe5l43ffjjjwo53oefpmhha
Citation

Sayamwong E. Hammack, Kristen J. Richey, Linda R. Watkins, Steven F. Maier. "Chemical Lesion of the Bed Nucleus of the Stria Terminalis Blocks the Behavioral Consequences of Uncontrollable Stress." Behavioral Neuroscience 118.2 (2004) 443-448