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PNAS Plus Significance Statements
2017
Proceedings of the National Academy of Sciences of the United States of America
Preserved Fulltext
This study provides experimental support for the mechanism of proximity-mediated catalysis by a mitogenactivated protein (MAP) kinase. It describes how the transcription factor Ets-1 uses the cumulative effects of two suboptimal docking interactions, rather than a single canonical docking interaction, to enable a unique bipartite mechanism of recognition of the MAP kinase ERK2. This mode of interaction between Ets-1 and ERK2 facilitates the formation of a highly productive complex that not only
doi:10.1073/pnas.ss11431
fatcat:ube53hhixvectdsyvbymy6vw2e