Effect of Anti-B7-1 and Anti-B7-2 mAb on Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease

Atsushi Inoue, Chang-Sung Koh, Masashi Yamazaki, Hideo Yagita
1999 Journal of Immunology  
We examined the role of B7-1 and B7-2, costimulatory molecules critical to full activation of T cells, in the development of Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD). Treatment with mAbs to B7-1 resulted in significant suppression of the development of this disease both clinically and histologically. In mice treated with these mAbs, the production of TNF-α and IFN-γ in the spleen cells was decreased. The delayed-type hypersensitivity and T cell
more » ... ive response specific for TMEV were decreased by this treatment. In contrast, treatment with Abs to B7-2, resulted in no effect on TMEV-IDD. These data suggest that B7-1 is critically involved in the pathogenesis of TMEV-IDD and that Abs to B7-1 could be a novel therapeutic approach in the clinical treatment of demyelinating diseases such as human multiple sclerosis.
doi:10.4049/jimmunol.163.11.6180 fatcat:dqnv3e3c6jadrkukxfktdgg3gm