Tumor Metabolism and Neuroimaging: Proton Magnetic Resonance Spectroscopy in Cerebral Glioma

Brandon Muncan
2017 Global Journal of Intellectual & Developmental Disabilities  
Axonal viability marker; highest peak in normal brain; peaks at 2.02ppm. Glob J Intellect Dev Disabil 2(3): GJIDD.MS.ID.555589 (2017) 0078 Abstract The advent of nuclear neuroimaging techniques has vastly changed neurobiology and neuroscience from a bench-research oriented practice to a clinical sub discipline with diagnostic and therapeutic implications. In particular, magnetic resonance spectroscopy (MR spectroscopy) began as a tool in understanding cellular metabolism in tissues of the
more » ... te gland, kidney, and brain, and has since evolved into a useful diagnostic and prognostic tool in clinical neurology [1] . In this review, the use of proton MR spectroscopy in the diagnosis and grading of glioma is summarized. Figure 2: Metabolic comparison between normal brain tissue and low-grade glioma. Choline and creatinine peaks are elevated, N-acetylaspartate peak is depressed. Figure 3: Single-voxel proton MRS of a patient with a brainstem glioma. MRS shows elevated choline and creatinine peaks as well as a depressed N-acetylaspartate peak. Lactate and lipids are also present indicating a higher-grade lesion. How to cite this article: Brandon M, Liliana N.Tumor Metabolism and Neuroimaging: Proton Magnetic Resonance Spectroscopy in Cerebral Glioma. Glob J Intellect Dev Disabil. 2017; 2(3): 555589.
doi:10.19080/gjidd.2017.02.555589 fatcat:gxbbax2opbhi7idoirowebm2f4