Identification of Yield Coefficients in an E.coli Model – An Optimal Experimental Design Using Genetic Algorithms

Ana C.A. Veloso, I. Rocha, E.C. Ferreira
2004 IFAC Proceedings Volumes  
An optimal experimental design for yield coefficients estimation in an unstructured growth model of fed-batch fermentation of E. coli is presented. The feed profile is designed by optimisation of a scalar function based on the Fischer Information Matrix. A genetic algorithm is proposed as the optimisation method due to its efficiency and independence on the initial values.
doi:10.1016/s1474-6670(17)32557-0 fatcat:cfzd6iganzehhiw72r34lcsyma