Andrade-Cetto, Escandón-Rivera, S Garcia-Luna
2015 Archives • 2015 •   unpublished
Type 2 diabetes (T2D) is a public health problem in Mexico and worldwide. In 2012, the Mexican health services report found that 9.2% of the Mexican adult population has been diagnosed with diabetes. Type 2 diabetes is characterized by tissue resistance to the action of insulin, combined with a relative deficiency in insulin secretion. A given individual may exhibit either increased insulin resistance or increased b cell deficiency, and these abnormalities may be mild or severe. In our country,
more » ... the use of medicinal plants is a common practice among people with the disease. In the towns of Tlanchinol and San Salvador hidalgo, Hamelia patens L. is in traditional use for the treatment of T2D. In this study, we tested the hypoglycemic effect of the water (W) and ethanol-water (E) extracts of Hamelia patens L. on streptozotocin nicotinamide hyperglycemic rats and found that both extracts exert a hypoglycemic effect at the doses tested. The water extract produces a statistically significant effect at 120 minutes, while the ethanol-water extracts produce a hypoglycemic effect at 60 min. We demonstrated the presence of at least three active compounds in the E extract: chlorogenic acid, caffeic acid and quercetin, and at least two active compounds in the W extract: chlorogenic acid and quercetin, which may be involved in the hypoglycemic effect. Rutin was not detected in the extracts but may be involved in the hypoglycemic effect. In conclusion, this study supports the traditional use of Hamelia patens as a hypoglycemic plant and correlates the main compounds (quercetin, chlorogenic and caffeic acids) with the effect.