Tracking algorithms chase down pathogens

Nicolas Chenouard, Alexandre Dufour, Jean-Christophe Olivo-Marin
2009 Biotechnology Journal  
Understanding sub-cellular dynamic processes governing pathogenic mechanisms is a necessary step towards the development of new drugs and strategies against infectious diseases. Sub-cellular pathogenic mechanisms, such as viral invasion processes involve highly dynamic nano-metric scale objects and rapid molecular interactions that require the study of individual particle paths. Single particle tracking methods allow to visualize and characterize the dynamics of biological objects and provide a
more » ... straightforward and accurate means to understand sub-cellular processes. This review describes a number of particle tracking methods in time-lapse microscopy sequences and provides examples of using such techniques to investigate mechanisms of host-pathogen interactions.
doi:10.1002/biot.200900030 pmid:19548236 fatcat:3lwppkwkf5a65oijoeyqlnzkhi