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Effects of selective degradation of the cohesin complex on higher order chromatin structures studied with live cell and super-resolved fluorescence microscopy
Biopolymers and Cell
The area around nuclear pores is enriched in open chromatin� Transcriptional factors and super enhancer sequences localize there during cell differentiation, activating sets of genes specific for a given tissue. Nucleoporin TPR is crucial for the enrichment of open chromatin around nuclear pores, however its role in gene expression and cell development has not been described yet� Here we show that depletion of TPR results in aberrant morphology of murine proliferating C2C12 myoblasts (MB) anddoi:10.7124/bc.0009a7 fatcat:fxaifn65cfccdgfv7ojb6zm5eq