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Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response
2018
Proceedings of the National Academy of Sciences of the United States of America
General control nonderepressible 2 (GCN2) plays a major role in the cellular response to amino acid limitation. Although maintenance of amino acid homeostasis is critical for tumor growth, the contribution of GCN2 to cancer cell survival and proliferation is poorly understood. In this study, we generated GCN2 inhibitors and demonstrated that inhibition of GCN2 sensitizes cancer cells with low basallevel expression of asparagine synthetase (ASNS) to the antileukemic agent L-asparaginase (ASNase)
doi:10.1073/pnas.1805523115
pmid:30061420
fatcat:x44th6umkbfrjpo4nxyef2yyae