The role of the gluten free diet in multiple sclerosis: data analysis with emphasis on pediatric patients [article]

Νικολέτα Βακρατσά, University Of Thessaly, Δημήτριος Μπόγδανος
2020
Multiple sclerosis affects 2.5 million people worldwide and is the leading cause of disability in young adults in the US. Recent studies have demonstrated the contribution of diet during the disease and there is a growing interest in the role of gluten in multiple sclerosis.However, there is still insufficient evidence for the role of gluten in the outcome of multiple Objective: The purpose of this thesis is to investigate whether there is sufficient nutritional research data in pediatric
more » ... le sclerosis patients and whether there is evidence to support the positive contribution of gluten-free nutrition to these patients as well as to the adult population. Methodology: Extensive literature searches were conducted on electronic databases such as PubMed, Scopus, Google and in online Greek and English-speaking multiple sclerosis, celiac disease and gluten organizations. Finally, popular webpages and specialist scientists from abroad were cited while various prevalent views were expressed about the role that gluten plays in recent times. Results: Vaccination with rHBv at age of 6 did not increase the production of autoantibodies and was therefore not associated with the onset of autoimmune disease. The gluten-free diet in 117 patients with celiac disease improved seizures and neuropsychiatric symptoms. In 75 patients with celiac disease, the lesions in the white substance were not affected by the administration of a gluten-free diet. In a 16-year-old patient with multiple sclerosis and celiac disease, the gluten-free diet improved the symptomatology. In a 4-year-old patient's survey with acute encephalomyelitis and celiac disease, gluten administration enhanced the symptomatology as well as in a study of an 8-year-old patient with bilateral optic neuritis, abdominal symptoms and a history of celiac disease. Conclusion: No study has been found to date showing the contribution of a gluten-free diet to adult and pediatric patients suffering from multiple sclerosis without celiac disease. Further studies are needed to clarify the role of nutrition and in particular the role of gluten affecting the disease's course and overall the quality of life in patients with multiple sclerosis.
doi:10.26253/heal.uth.8426 fatcat:xuov23dprrcgtjnbxck2rsrtym