Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population

Na-Ping Tang, Lian-Sheng Wang, Li Yang, Bo Zhou, Hai-Juan Gu, Qing-Min Sun, Ri-Hong Cong, Huai-Jun Zhu, Bin Wang
2007 Journal of Lipid Research  
The aim of the present study was to assess the influence of the endothelial lipase (EL) gene 584C/T variant, which results in a change at codon 111 of the EL gene from threonine to isoleucine, on the risk of coronary artery disease (CAD) in a Chinese population. The study population consisted of 265 CAD patients and 265 age-and sexmatched control subjects. The T allele frequency was significantly lower among CAD patients than among control subjects (18.3% vs. 29.8%; P , 0.001). In both the CAD
more » ... nd control groups, the T allele carriers had higher high density lipoprotein cholesterol (HDL-C) levels than homozygote C allele carriers. In a multiple logistic regression model adjusted for age, sex, body mass index, smoking, hypertension, diabetes, hyperlipidemia, and low density lipoprotein cholesterol, a significantly decreased risk of developing CAD was found in subjects carrying a variant CT or TT genotype (odds ratio 5 0.496, 95% confidence interval 5 0.341-0.723; P , 0.001), and the significance persisted after further adjustment for HDL-C. In conclusion, our observation that the EL 584T allele was associated with protection from CAD in this Chinese population replicates the findings in a Japanese study, which found a similar association of this allele with acute myocardial infarction, independent of HDL-C levels.-Tang, N-P., L-Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population.
doi:10.1194/jlr.m700399-jlr200 pmid:17986713 fatcat:yfjgld5ly5bshf7gpcd46r62re