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Gastrin and Glycine-extended Progastrin Processing Intermediates Induce Different Programs of Early Gene Activation
1995
Journal of Biological Chemistry
We recently reported that gastrin and glycine-extended progastrin processing intermediates (G-Gly) exert growth-promoting effects on AR4 -2J cells (derived from rat pancreas) via interaction with distinct receptors. In this study we sought to investigate the mechanisms by which gastrin and G-Gly stimulate cell proliferation. While gastrin increased [Ca 2؉ ] i in AR4 -2J cells, G-Gly had no effect. Similarly, G-Gly had no effect either on basal and 10 ؊7 M vasoactive intestinal
doi:10.1074/jbc.270.47.28337
pmid:7499334
fatcat:i3hvbkjf2bbqdoqvrtbelaee3m