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Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway
2021
Cell Reports
Mechanisms have evolved that allow cells to detect signals and generate an appropriate response. The accuracy of these responses relies on the ability of cells to discriminate between signal and noise. How cells filter noise in signaling pathways is not well understood. Here, we analyze noise suppression in the yeast pheromone signaling pathway and show that the poorly characterized protein Kel1 serves as a major noise suppressor and prevents cell death. At the molecular level, Kel1 prevents
doi:10.1016/j.celrep.2021.110186
pmid:34965431
fatcat:hikirg25dbadrdf6kaotw2o35a