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The genetic background modulates the evolution of fluoroquinolone-resistance in Mycobacterium tuberculosis
Fluoroquinolones (FQ) form the backbone in experimental treatment regimens against drug-susceptible tuberculosis. However, little is known on whether the genetic variation present in natural populations of Mycobacterium tuberculosis (Mtb) affects the evolution of FQ-resistance (FQ-R). To investigate this question, we used nine genetically distinct drugsusceptible clinical isolates of Mtb and measured their frequency of resistance to the FQ ofloxacin (OFX) in vitro. We found that the Mtb geneticdoi:10.5451/unibas-ep75536 fatcat:sxcpp4dr2nggnlhxer4laefgue