About the influence of metal oxide nanoparticles on living organisms physiology

Orkhan А. Zeinalov, Svetlana P. Kombarova, Dmitry V. Bagrov, Mariya A. Petrosyan, Gulrukhsor H. Tolibova, Alexey V. Feofanov, Konstantin V. Shaitan
2016 Reviews on Clinical Pharmacology and Drug Therapy  
Recently the number of materials and goods produced by nanotechnology has been growing rapidly, leading to an increased penetration of nanoparticles into biosystems. To assess the risks associated with the production and circulation of nanoproducts should be developed methods for the rapid diagnostics of nanopathology. In this work, it has been experimentally shown that the introduction of metal oxides nanoparticles (TiO2, ZnO, Al2O3, CeO2) to laboratory mice leads to changes some profiles of
more » ... ecific hematological and biochemical blood parameters. Therefore for the purpose of early detection of symptoms of intoxication as benchmarks of the influence of metal oxide nanoparticles on living organisms can recommend express monitoring of peripheral blood (red blood parameters) and biochemical parameters of blood serum (activity of aminotransferases and indicators of nitrogen metabolism). The chosen indicators of blood can serve as diagnostic biomarkers in the development of rapid tests of primary monitoring of the impact of metal oxide nanoparticles on biological systems.
doi:10.17816/rcf14324-33 fatcat:pff422tiwnelvkkvvvz5xkac5e