Catalytic enantioselective synthesis of perfluoroalkyl-substituted β-lactones via a concerted asynchronous [2+2] cycloaddition: A synthetic and computational study

Diego Barrios Antunez, Mark Greenhalgh, Alexander C Brueckner, Daniel M Walden, Pilar Elías-Rodríguez, Patrick Roberts, Benjamin Young, Thomas West, Alexandra Slawin, Paul Ha Yeon Cheong, Andrew D Smith
<span title="2019-04-29">2019</span> <i title="Royal Society of Chemistry (RSC)"> <a target="_blank" rel="noopener" href="" style="color: black;">Chemical Science</a> </i> &nbsp;
The enantioselective preparation of a range of perfluoroalkyl-substituted β-lactones through an isothiourea (HyperBTM) catalysed reaction using symmetric anhydrides as ammonium enolate precursors and perfluoroalkylketones (RF = CF3, C2F5, C4F9) is...
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1039/c9sc00390h</a> <a target="_blank" rel="external noopener" href="">pmid:31360423</a> <a target="_blank" rel="external noopener" href="">pmcid:PMC6585878</a> <a target="_blank" rel="external noopener" href="">fatcat:svbn7b2zsjbsdcb5ix3dawwl7i</a> </span>
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