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Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity
2021
eLife
Mortality from breast cancer is almost exclusively a result of tumor metastasis, and lungs are one of the main metastatic sites. Cancer-associated fibroblasts (CAFs) are prominent players in the microenvironment of breast cancer. However, their role in the metastatic niche is largely unknown. In this study, we profiled the transcriptional co-evolution of lung fibroblasts isolated from transgenic mice at defined stage-specific time points of metastases formation. Employing multiple
doi:10.7554/elife.60745
pmid:34169837
pmcid:PMC8257251
fatcat:ohkhgkxwxzepxct5ton52i4uhq