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Hif-1α stabilisation polarises macrophages via cyclooxygenase/prostaglandin E2 in vivo
[article]
2019
bioRxiv
pre-print
Macrophage subtypes are poorly characterised in disease systems in vivo. The initial innate immune response to injury and infectious stimuli through M1 polarisation is important for the outcome of disease. Appropriate macrophage polarisation requires complex coordination of local microenvironmental cues and cytokine signalling to influence immune cell phenotypes. If the molecular mechanisms behind macrophage polarisation were better understood then macrophages could be pharmacologically tuned
doi:10.1101/536862
fatcat:qjsx5lfddvcddbreajpejhxriy