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After half a century of success in combating infectious diseases with vaccination and antibiotics, emerging and reemerging epidemics present a new threat to human health. Meanwhile, the rapid pace of viral and microbial genomics research, largely based on the success of genomics technologies, offers new data-generating platforms and a revolutionary knowledge base for better understanding the diseases and the associated pathogens. Systematic molecular biology studies using genomics informationdoi:10.1146/annurev.genom.9.081307.164428 pmid:18767959 fatcat:bsl5zlre4vbm5bwz3vg36a6ppy