The Face-Processing Network Is Resilient to Focal Resection of Human Visual Cortex

K. S. Weiner, J. Jonas, J. Gomez, L. Maillard, H. Brissart, G. Hossu, C. Jacques, D. Loftus, S. Colnat-Coulbois, A. Stigliani, M. A. Barnett, K. Grill-Spector (+1 others)
<span title="2016-08-10">2016</span> <i title="Society for Neuroscience"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s7bticdwizdmhll4taefg57jde" style="color: black;">Journal of Neuroscience</a> </i> &nbsp;
Human face perception requires a network of brain regions distributed throughout the occipital and temporal lobes with a right hemisphere advantage. Present theories consider this network as either a processing hierarchy beginning with the inferior occipital gyrus (occipital face area; IOG-faces/OFA) or a multiple-route network with nonhierarchical components. The former predicts that removing IOG-faces/OFA will detrimentally affect downstream stages, whereas the latter does not. We tested this
more &raquo; ... prediction in a human patient (Patient S.P.) requiring removal of the right inferior occipital cortex, including IOG-faces/OFA. We acquired multiple fMRI measurements in Patient S.P. before and after a preplanned surgery and multiple measurements in typical controls, enabling both within-subject/ across-session comparisons (Patient S.P. before resection vs Patient S.P. after resection) and between-subject/across-session comparisons (Patient S.P. vs controls). We found that the spatial topology and selectivity of downstream ipsilateral face-selective regions were stable 1 and 8 month(s) after surgery. Additionally, the reliability of distributed patterns of face selectivity in Patient S.P. before versus after resection was not different from across-session reliability in controls. Nevertheless, postoperatively, representations of visual space were typical in dorsal face-selective regions but atypical in ventral face-selective regions and V1 of the resected hemisphere. Diffusion weighted imaging in Patient S.P. and controls identifies white matter tracts connecting retinotopic areas to downstream face-selective regions, which may contribute to the stable and plastic features of the face network in Patient S.P. after surgery. Together, our results support a multiple-route network of face processing with nonhierarchical components and shed light on stable and plastic features of high-level visual cortex following focal brain damage.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1523/jneurosci.4509-15.2016">doi:10.1523/jneurosci.4509-15.2016</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27511014">pmid:27511014</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4978802/">pmcid:PMC4978802</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/timxe6r54rc2pdcyx4srqsjosi">fatcat:timxe6r54rc2pdcyx4srqsjosi</a> </span>
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